Fecha de publicación: 01/10/2022
Autores: Flook M, Escalera-Balsera A, Gallego-Martinez A, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Lopez-Escamez JA.
Abstract: No epigenetic studies have been performed on Meniere disease. We performed whole-genome bisulfite sequencing in 14 MD patients and six controls. We have also found 12 undermethylated regions (UMR) that were exclusive to MD, including two UMR in an inter CpG island in the PHB gene. We suggest that the DNA methylation signature allows distinguishing between MD patients and controls. The enrichment analysis confirms previous findings of a chronic inflammatory process.
Área de la especialidad: Otoneurologia
Datos bibliográficos: Flook M, Escalera-Balsera A, Gallego-Martinez A, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Lopez-Escamez JA. DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease. Biomedicines. 2021 Oct 25;9(11):1530. doi: 10.3390/biomedicines9111530. PMID: 34829759; PMCID: PMC8615058.