Fecha de publicación: 01/10/2022

Autores: Flook M, Escalera-Balsera A, Gallego-Martinez A, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Lopez-Escamez JA.

Abstract: No epigenetic studies have been performed on Meniere disease. We performed whole-genome bisulfite sequencing in 14 MD patients and six controls. We have also found 12 undermethylated regions (UMR) that were exclusive to MD, including two UMR in an inter CpG island in the PHB gene. We suggest that the DNA methylation signature allows distinguishing between MD patients and controls. The enrichment analysis confirms previous findings of a chronic inflammatory process.

Área de la especialidad: Otoneurologia

Datos bibliográficos: Flook M, Escalera-Balsera A, Gallego-Martinez A, Espinosa-Sanchez JM, Aran I, Soto-Varela A, Lopez-Escamez JA. DNA Methylation Signature in Mononuclear Cells and Proinflammatory Cytokines May Define Molecular Subtypes in Sporadic Meniere Disease. Biomedicines. 2021 Oct 25;9(11):1530. doi: 10.3390/biomedicines9111530. PMID: 34829759; PMCID: PMC8615058.

Fecha de publicación: 01/05/2021

Autores: Moleon MDC, Torres-Garcia L, Batuecas-Caletrio A, Castillo-Ledesma N, Gonzalez-Aguado R, Magnoni L, Rossi M, Di Berardino F, Perez-Guillen V, Trinidad-Ruiz G, Lopez-Escamez JA.

Abstract: Meniere disease (MD) is defined by a clinical syndrome of recurrent attacks of spontaneous vertigo associated with tinnitus, aural fullness, and sensorineural hearing loss (SNHL). A predictive model including the age of onset, high frequency HL in the first audiogram and migraine can help to assess the risk of bilateral SNHL in MD. This model may have significant implications for clinical management of patients with MD.

Área de la especialidad: Otoneurologia

Datos bibliográficos: Moleon MDC, Torres-Garcia L, Batuecas-Caletrio A, Castillo-Ledesma N, Gonzalez-Aguado R, Magnoni L, Rossi M, Di Berardino F, Perez-Guillen V, Trinidad-Ruiz G, Lopez-Escamez JA. A Predictive Model of Bilateral Sensorineural Hearing Loss in Meniere Disease Using Clinical Data. Ear Hear. 2022 May/Jun;43(3):1079-1085. doi: 10.1097/AUD.0000000000001169. PMID: 34799494.

Fecha de publicación: 09/12/2021

Autores: O’Connor-Reina, C.; Ignacio Garcia, J.M.; Rodriguez Alcala, L.; Rodríguez Ruiz, E.; Garcia Iriarte, M.T.; Casado Morente, J.C.; Baptista, P.; Plaza, G.

Abstract: Myofunctional therapy (MT) is used to treat sleep-disordered breathing. However, MT has low adherence—only ~10% in most studies. We describe our experiences with MT delivered through a mobile health app named Airway Gym®, which is used by patients who have rejected continuous positive airway pressure and other therapies. We compared ear, nose, and throat examination findings, Friedman stage, tongue-tie presence, tongue strength measured using the Iowa oral performance instrument (IOPI), and full

Área de la especialidad: RONCOPATIA Y TRASTORNOS RESPIRATORIOS DEL SUEÑO

Datos bibliográficos: O’Connor-Reina, C.; Ignacio Garcia, J.M.; Rodriguez Alcala, L.; Rodríguez Ruiz, E.; Garcia Iriarte, M.T.; Casado Morente, J.C.; Baptista, P.; Plaza, G. Improving Adherence to Myofunctional Therapy in the Treatment of Sleep-Disordered Breathing. J. Clin. Med. 2021, 10, 5772. https://doi.org/10.3390/jcm10245772

Fecha de publicación: Noviembre 2021

Autores: Elizabeth S Burckardt 1 , Gerardo Lopez-Guerra 1 , James B Kobler 1 , Monica A Tynan 1 , Robert H Petrillo 1 , Jarrad H Van Stan 1 , James A Burns 1 – 1 Department of Surgery, Harvard Medical School, Center for Laryngeal Surgery and Voice Rehabilitation, Massachusetts General Hospital, Boston, Massachusetts, U.S.A.

Abstract: Anatomic consistency in cricoarytenoid anatomy provides reliable surgical landmarks for ideal placement of an arytenopexy suture to optimally reposition the arytenoid cartilage. Optimal arytenoid medialization can be accurately reproduced with an arytenopexy-suture that is placed superior-medially on the cricoid facet.

Área de la especialidad: Laringología

Datos bibliográficos: PMID: 33864644 DOI: 10.1002/lary.29578

Fecha de publicación: 01/08/2021

Autores: Borrmann P, O’Connor-Reina C, Ignacio J, Rodriguez Ruiz E, Rodriguez Alcala L, Dzembrovsky F, Baptista P, Garcia Iriarte M, Casado Alba C, Plaza G

Abstract: Background:
Myofunctional therapy is currently a reasonable therapeutic option to treat obstructive sleep apnea-hypopnea syndrome (OSAHS). This therapy is based on performing regular exercises of the upper airway muscles to increase their tone and prevent their collapse. Over the past decade, there has been an increasing number of publications in this area; however, to our knowledge, there are no studies focused on patients who can most benefit from this therapy.

Área de la especialidad: RONCOPTIA Y TRASTORNOS RESPIRATORIOS DEL SUEÑO

Datos bibliográficos: JMIR Res Protoc 2021;10(8):e30500 URL: https://www.researchprotocols.org/2021/8/e30500 DOI: 10.2196/30500

Fecha de publicación: 15/09/2021

Autores: Roman-Naranjo P, Moleon MDC, Aran I, Escalera-Balsera A, Soto-Varela A, Bächinger D, Gomez-Fiñana M, Eckhard AH, Lopez-Escamez JA.

Abstract: Familial Meniere disease shows a co-segregation of rare variants in the MYO7A gene and other structural myosin VIIA binding proteins involved in the tip and ankle links of the hair cell stereocilia. We suggest that recessive digenic inheritance involving these genes could affect the ultrastructure of the stereocilia links in familial MD.

Área de la especialidad: Otoneurologia

Datos bibliográficos: 1. Roman-Naranjo P, Moleon MDC, Aran I, et al. Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease. Hear Res. 2021;409:108329. doi:10.1016/j.heares.2021.108329

Fecha de publicación: 01/04/2021

Autores: Sana Amanat, Álvaro Gallego-Martinez, Joseph Sollini, Patricia Perez-Carpena, Juan M. Espinosa-Sanchez, Ismael Aran, Andres Soto-Varela, Angel Batuecas,…

Abstract: A burden of rare variants in ANK2, AKAP9 and TSC2 genes is associated with severe tinnitus. ANK2, encodes a cytoskeleton scaffolding protein that coordinates the assembly of several proteins, drives axonal branching and influences connectivity in neurons.

Área de la especialidad: Audiología

Datos bibliográficos: Amanat S, Gallego-Martinez A, Sollini J, et al. Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine. 2021;66:103309. doi:10.1016/j.ebiom.2021.103309

Fecha de publicación: 30/06/2021

Autores: O’Connor Reina C, García JM, Baptista P. et al.

Abstract: We present the first case of a patient with obstructive sleep apnea syndrome (OSA), where drug induced sleep endoscopy was helpful to suspect a non-acid reflux disease and showed an improvement in a swollen epiglottis after treatment. Patient ameliorated significantly his disease only with medical therapy.

Área de la especialidad: Roncopatía y trastornos respiratorios del sueño

Datos bibliográficos: Journal of Otolaryngol – Head & Neck Surg 50, 42 (2021). https://doi.org/10.1186/s40463-021-00526-w

Fecha de publicación: 18/02/2021

Autores: Laura Rodríguez-Alcalá, Juan Martín-Lagos Martínez, Carlos O´Connor-Reina, Guillermo Plaza

Abstract: The study of the muscles of the tongue forms part of a basic evaluation of upper airway function that includes swallowing, speaking and chewing. It is important because the upper airway presents a region of collapse during sleep. Through the action of the dilator muscles, mainly the genioglossus, such collapse can be prevented. In this study, we present a simple tool that can be used to measure the strength of the tongue. This tool may provide an easy way to measure tongue function and allow

Área de la especialidad: Roncopatía y trastornos respiratorios del sueño

Datos bibliográficos: Rodríguez-Alcalá L, Martín-Lagos Martínez J, O´Connor-Reina C, Plaza G (2021) Assessment of muscular tone of the tongue using a digital measure spoon in a healthy population: A pilot study. PLoS ONE 16(2): e0245901. https://doi.org/10.1371/journal.pone.0245901

Fecha de publicación: 26/01/2021

Autores: McKeown P, O’Connor-Reina C, Plaza G.

Abstract: Four phenotypes of obstructive sleep apnea hypopnea syndrome (OSAHS) have been identified. Only one of these is anatomical. As such, anatomically based treatments for OSAHS may not fully resolve the condition. Equally, compliance and uptake of gold-standard treatments is inadequate. This has led to interest in novel therapies that provide the basis for personalized treatment protocols. This review examines each of the four phenotypes of OSAHS and explores how these could be targeted using breath

Área de la especialidad: Roncopatia y trastornos respiratorios del sueño

Datos bibliográficos: Journal of Clinical Medicine. 2021; 10(3):471. https://doi.org/10.3390/jcm10030471