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Muscular Assessment in Patients With Severe Obstructive Sleep Apnea Syndrome: Protocol for a Case-Control Study J

Fecha de publicación: 01/08/2021

Autores: Borrmann P, O’Connor-Reina C, Ignacio J, Rodriguez Ruiz E, Rodriguez Alcala L, Dzembrovsky F, Baptista P, Garcia Iriarte M, Casado Alba C, Plaza G

Abstract: Background:
Myofunctional therapy is currently a reasonable therapeutic option to treat obstructive sleep apnea-hypopnea syndrome (OSAHS). This therapy is based on performing regular exercises of the upper airway muscles to increase their tone and prevent their collapse. Over the past decade, there has been an increasing number of publications in this area; however, to our knowledge, there are no studies focused on patients who can most benefit from this therapy.

Área de la especialidad: RONCOPTIA Y TRASTORNOS RESPIRATORIOS DEL SUEÑO

Datos bibliográficos: JMIR Res Protoc 2021;10(8):e30500 URL: https://www.researchprotocols.org/2021/8/e30500 DOI: 10.2196/30500

Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease.

Fecha de publicación: 15/09/2021

Autores: Roman-Naranjo P, Moleon MDC, Aran I, Escalera-Balsera A, Soto-Varela A, Bächinger D, Gomez-Fiñana M, Eckhard AH, Lopez-Escamez JA.

Abstract: Familial Meniere disease shows a co-segregation of rare variants in the MYO7A gene and other structural myosin VIIA binding proteins involved in the tip and ankle links of the hair cell stereocilia. We suggest that recessive digenic inheritance involving these genes could affect the ultrastructure of the stereocilia links in familial MD.

Área de la especialidad: Otoneurologia

Datos bibliográficos: 1. Roman-Naranjo P, Moleon MDC, Aran I, et al. Rare coding variants involving MYO7A and other genes encoding stereocilia link proteins in familial meniere disease. Hear Res. 2021;409:108329. doi:10.1016/j.heares.2021.108329

Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study.

Fecha de publicación: 01/04/2021

Autores: Sana Amanat, Álvaro Gallego-Martinez, Joseph Sollini, Patricia Perez-Carpena, Juan M. Espinosa-Sanchez, Ismael Aran, Andres Soto-Varela, Angel Batuecas,…

Abstract: A burden of rare variants in ANK2, AKAP9 and TSC2 genes is associated with severe tinnitus. ANK2, encodes a cytoskeleton scaffolding protein that coordinates the assembly of several proteins, drives axonal branching and influences connectivity in neurons.

Área de la especialidad: Audiología

Datos bibliográficos: Amanat S, Gallego-Martinez A, Sollini J, et al. Burden of rare variants in synaptic genes in patients with severe tinnitus: An exome based extreme phenotype study. EBioMedicine. 2021;66:103309. doi:10.1016/j.ebiom.2021.103309

Non Acid Reflux and Sleep Apnea: the importance of Drug Induced Sleep Endoscopy

Fecha de publicación: 30/06/2021

Autores: O’Connor Reina C, García JM, Baptista P. et al.

Abstract: We present the first case of a patient with obstructive sleep apnea syndrome (OSA), where drug induced sleep endoscopy was helpful to suspect a non-acid reflux disease and showed an improvement in a swollen epiglottis after treatment. Patient ameliorated significantly his disease only with medical therapy.

Área de la especialidad: Roncopatía y trastornos respiratorios del sueño

Datos bibliográficos: Journal of Otolaryngol – Head & Neck Surg 50, 42 (2021). https://doi.org/10.1186/s40463-021-00526-w

Assessment of muscular tone of the tongue using a digital measure spoon in a healthy population: A pilot study

Fecha de publicación: 18/02/2021

Autores: Laura Rodríguez-Alcalá, Juan Martín-Lagos Martínez, Carlos O´Connor-Reina, Guillermo Plaza

Abstract: The study of the muscles of the tongue forms part of a basic evaluation of upper airway function that includes swallowing, speaking and chewing. It is important because the upper airway presents a region of collapse during sleep. Through the action of the dilator muscles, mainly the genioglossus, such collapse can be prevented. In this study, we present a simple tool that can be used to measure the strength of the tongue. This tool may provide an easy way to measure tongue function and allow

Área de la especialidad: Roncopatía y trastornos respiratorios del sueño

Datos bibliográficos: Rodríguez-Alcalá L, Martín-Lagos Martínez J, O´Connor-Reina C, Plaza G (2021) Assessment of muscular tone of the tongue using a digital measure spoon in a healthy population: A pilot study. PLoS ONE 16(2): e0245901. https://doi.org/10.1371/journal.pone.0245901

Breathing Re-Education and Phenotypes of Sleep Apnea: A Review.

Fecha de publicación: 26/01/2021

Autores: McKeown P, O’Connor-Reina C, Plaza G.

Abstract: Four phenotypes of obstructive sleep apnea hypopnea syndrome (OSAHS) have been identified. Only one of these is anatomical. As such, anatomically based treatments for OSAHS may not fully resolve the condition. Equally, compliance and uptake of gold-standard treatments is inadequate. This has led to interest in novel therapies that provide the basis for personalized treatment protocols. This review examines each of the four phenotypes of OSAHS and explores how these could be targeted using breath

Área de la especialidad: Roncopatia y trastornos respiratorios del sueño

Datos bibliográficos: Journal of Clinical Medicine. 2021; 10(3):471. https://doi.org/10.3390/jcm10030471

Myofunctional Therapy App for Severe Apnea–Hypopnea Sleep Obstructive Syndrome: Pilot Randomized Controlled Trial

Fecha de publicación: 09/11/2020

Autores: Carlos O’Connor-Reina1,2*, MD, PhD ; Jose Maria Ignacio Garcia3,4*, MD, PhD ; Elisa Rodriguez Ruiz3*, BS, MS ; Maria Del Carmen Morillo Dominguez3*, MD ; Victoria Ignacio Barrios3,4*, MD ; Peter Baptista Jardin5*, MD, PhD ; Juan Carlos Casado Morente1,2*, MD, PhD ; Maria Teresa Garcia Iriarte6*, MD, PhD ; Guillermo Plaza7,8*, MD, PhD

Abstract: Background: Myofunctional therapy has demonstrated efficacy in treating sleep-disordered breathing. We assessed the clinical use of a new mobile health (mHealth) app that uses a smartphone to teach patients with severe obstructive sleep apnea–hypopnea syndrome (OSAHS) to perform oropharyngeal exercises.

Objective: We conducted a pilot randomized trial to evaluate the effects of the app in patients with severe OSAHS.

Methods: Forty patients with severe OSAHS (apnea–hypoxia index [AHI]>30) were

Área de la especialidad: RONCOPATIA Y TRASTORNOS RESPIRATORIOS DEL SUENO

Datos bibliográficos: O’Connor-Reina C, Ignacio Garcia JM, Rodriguez Ruiz E, Morillo Dominguez MDC, Ignacio Barrios V, Baptista Jardin P, Casado Morente JC, Garcia Iriarte MT, Plaza G
Myofunctional Therapy App for Severe Apnea–Hypopnea Sleep Obstructive Syndrome: Pilot Randomized Controlled Trial
JMIR Mhealth Uhealth 2020;8(11):e23123
URL: https://mhealth.jmir.org/2020/11/e23123
DOI: 10.2196/23123
PMID: 33093013

New mHealth application software based on myofunctional therapy applied to sleep-disordered breathing in non-compliant subjects

Fecha de publicación:05/02/2020

Autores: CARLOS O´CONNOR REINA, GUILLERMO PLAZA, JOSE MARIA IGNACIO GARCIA, PETER BAPTISTA JARDIN, MARIA TERESA GARCIA IRIARTE, JUAN CARLOS CASADO MORENTE, EUGENIO DE VICENTE, AGUSTIN RODRIGUEZ

Abstract: Background
Myofunctional therapy (MT) is a therapeutic option with demonstrated efficacy for treating sleep-disordered breathing. We assessed the clinical application of a newly developed m-Health App, which aimed to allow patients with OSAHS (obstructive sleep apnea/hypopnea syndrome) to perform oropharyngeal exercises only by interacting with their smartphone without no other devices.

Área de la especialidad: MEDICINA DEL SUEÑO

Datos bibliográficos: Cite this article
O’Connor Reina, C., Plaza, G., Ignacio-Garcia, J.M. et al. New mHealth application software based on myofunctional therapy applied to sleep-disordered breathing in non-compliant subjects. Sleep Science Practice 4, 3 (2020). https://doi.org/10.1186/s41606-019-0040-8

Teratoma tiroideo en el adulto. Revisión de la bibliografía y presentación de un caso.

Fecha de publicación: 01/02/2020

Autores: Moreno Valor, Ana; Pagalday, Lide; García Martín, Mikel; Torrico Román, Pablo.

Abstract: Los teratomas son entidades raras en la glándula tiroides, sobre todo en adultos.
Presentamos el caso de un paciente de 42 años que acude por tumoración cervical de meses de evolución y disfagia.
Se realiza estudio de la lesión clasificándose como teratoma tiroideo maduro.

Área de la especialidad: Cirugía de cabeza y cuello

Datos bibliográficos: 1) P. Torrico Román, J. Pando Pinto, T. Mogollón Cano-Cortés, A. Blasco Huelva, R. Soria Corón. Teratomas tiroideos del adulto. Acta Otorrinolaring. Esp. 1999; 50, 1: 75-77.
2) Eunyoung Kim, Tae Seok Bae,Youngmee Kwon, Tae Hyun Kim, Ki-Wook Chung, Sun Wook Kim, Jungsil Ro, Eun Sook Lee. Primary Malignant Teratoma with a Primitive Neuroectodermal Tumor Component in Thyroid Gland: A Case Report. J Korean Med Sci 2007; 22: 568-71.
3) Renzo Ranaldi, M.D., Doriana Morichetti, M.D., Gaia Goteri, M.D., and Ascanio Martino, M.D. lmmature Teratoma of the Mediastinum Arising in Ectopic Thyroid Tissue.A Case Report. Anal Quant Cytol Histol 2009; 31:233-238.
4) Renate Pichler, Isabel Heidegger, Andrea Brunner, Hannes Steiner. Long-Term Follow-Up of a Primary Teratoma With Somatic-Type Malignancy Within the Thyroid Gland Mimicking Thyroid Carcinoma. Clinical Genitourinary Cancer. 2014;Vol. 12, No. 5, e221-4.
5) Eijun Nishihara, Akira Miyauchi, Mitsuyoshi Hirokawa, Takumi Kudo, Hidemi Ohye, Mitsuru Ito, Sumihisa Kubota, Shuji Fukata, Nobuyuki Amino, and Kanji Kuma. Benign Thyroid Teratomas Manifest Painful Cystic and Solid Composite Nodules. Three Case Reports and a Review of the Literature. Endocrine, vol. 30, no. 2, 231–236; October 2006. ENDO (online) ISSN 1559-0100.
6) Jose Ting, Diana Bell, Salmaan Ahmed, Anita Ying, Steven G.Waguespack, Shi-Ming Tu, Randal Weber, and Mark Zafereo. Primary malignant thyroid teratoma: an instutional experience. Thyroid, Vol. 29, No. 2. 26 Apr 2019. https://doi.org/10.1089/thy.2018.0206.
7) Gordan. M Vujanic, H.Rubén Harach, Predrag Minic, Nada Vuckovic. Thyroid/ cervical teratomas in children: Inmunohistochemical studies for specifics thyroid epithelial cell markers.Pediatric pathology.1993; 14:369-375.

Tongue peak pressure: a tool to aid in the identification of obstruction sites in patients with obstructive sleep apnea/hypopnea syndrome

Fecha de publicación: 19/11/2019

Autores: Carlos O’Connor-Reina ,Guillermo Plaza, Maria Teresa Garcia-Iriarte , Jose Maria Ignacio-Garcia , Peter Baptista , Juan Carlos Casado-Morente, & Eugenio De Vicente

Abstract: Purpose of this study was to evaluate whether tongue peak pressure measured using the Iowa Oral Performance Instrument is correlated with the topographic site of obstruction in patients with obstructive sleep apnea/hypopnea syndrome observed during drug-induced sleep endoscopy. Thirty-five consecutive adult patients (29 men, 6 women) were prospectively enrolled after having been diagnosed with severe obstructive sleep apnea/hypopnea syndrome by polysomnography. An apnea-hypopnea index > 30 was c

Área de la especialidad: RONQUIDO Y TRASTORNOS RESPIRATORIOS DEL SUEÑO

Datos bibliográficos: O’Connor-Reina, C., Plaza, G., Garcia-Iriarte, M.T. et al. Sleep Breath (2019). https://doi.org/10.1007/s11325-019-01952-x